Hi community,
I have a clinical study with the following design:
- 60 patients studied
- 30 patients in the untreated group (group 1)
- 30 patients in the treated group (group 2)
Each patient was measured et 3 times D0, D1,D2:
- D0 is the measure before any treatment (for the two groups)
- D1/D2 are the measures after 1 (resp. 2) months for group 1
- D1/D2 are the measures after 1 (resp. 2) months of treatment for group 2
The questions are:
- For each time: compare the two groups
- For each group : compare the three times (by pairs)
I wanted to apply a multilevel analysis on the patient to remove the inter-patients variability (and better see the effects between times). But I think it is not correct for comparing the two groups for each time (multilevel analysis introduce bias in this comparison). Do you agree with that ?
What do you recommend in this case ? Perform 3 analyses ?
- The first one on the group 1 only after multilevel
- The second one on the group 2 only with multilevel
- The third to compare the groups at each tile (without applying multilevel)
Thanks a lot for your help,
Best regards,
Eléonore