I have been exploring DIABLO for integrating 4 omics types using different design matrices (weighted and full). In DIABLO objects of my analysis, I see the below. What does the
$weights mean here? Is there any reference material that describes how to interpret these weights?
diabloFulldes$weights comp1 comp2 mRNA 0.7840607 0.5215328 proteinO 0.6266970 0.5001603 proteinS 0.5434681 0.4893959 metabolite 0.5143882 0.3633174 > diabloWtdes1$weights comp1 comp2 mRNA 0.3545887 0.5443691 proteinO 0.4175279 0.5101271 proteinS 0.4444788 0.5067080 metabolite 0.3408058 0.3480089 > diabloWtdes2$weights comp1 comp2 mRNA 0.7840607 0.5215328 proteinO 0.6266970 0.5001603 proteinS 0.5434681 0.4893959 metabolite 0.5143882 0.3633174
It says from the
help that it is the Correlation between the variate of each block and the variate of the outcome. Used to weight predictions. So can this be interpreted as mRNA analytes (selected) in
comp2 correlate with phenotypic outcome 78.4% and 52.15% in
diabloFulldes while in
diabloWtdes1 the correlation of mRNA analytes in
comp2 with the phenotypic outcome is 35.4% and 54.4% respectively?