Sparce CCA paired DATA

I just want to ask if we can use the sparse CCA method for paired data.

Thank you for your help.

dear @Yasyou,
it depends what you define by paired data!

Same samples measured across 2 omics: yes
Samples measured twice (i.e. before/after): you would need to account for the repeated measurements using a multilevel approach. There has been quite some discussions already on that topic if you search, for example: sPLS-DA model for repeated longitudinal measurements - #2 by kimanh.lecao